Super Vilitra should not be used without medical supervision by several groups, because it combines two active drugs (a PDE5 inhibitor + a serotonin-related medication), which increases the risk of side effects and drug interactions. Here are the main groups who should avoid self-medicating with it: People with heart or blood pressure problems Anyone with recent heart attack, stroke, severe chest pain (angina), or serious heart rhythm disorders should avoid it. It can lower blood pressure and strain the heart, especially during ***** activity. Those with very low blood pressure or uncontrolled high blood pressure are also at risk. People taking nitrate medicines or nitric oxide donors If someone uses medications like nitroglycerin for chest pain, combining them with vardenafil can cause a dangerous drop in blood pressure.