Tadarise 2.5 mg should not be combined with nitrates, such as nitroglycerin, isosorbide mononitrate, or isosorbide dinitrate, because the blood pressure drop can be dangerous. It should also not be used with riociguat, a guanylate cyclase stimulator, for the same reason. Other medicines to avoid or check carefully Other erectile dysfunction medicines, such as sildenafil, vardenafil, or avanafil, unless a clinician specifically says otherwise. Alpha-blockers used for prostate problems or high blood pressure, because the combination can cause dizziness or low blood pressure. Strong CYP3A4 inhibitors, which can raise tadalafil levels; examples include some HIV and hepatitis C medicines. Also important Tadarise is a tadalafil product, so these interaction warnings apply to tadalafil generally. Alcohol and blood-pressure-lowering drugs can also increase side effects or make dizziness more likely. Do not start or stop any interacting medicine without checking with a clinician or pharmacist first.