Cenforce D you mean the combination of sildenafil + dapoxetine, the sildenafil component begins increasing blood flow to the ***** as it is absorbed, typically within 30–60 minutes. Peak blood levels are usually reached around 1 hour when taken on an empty stomach. D DailyMed +1 A few important points: You still need ***** stimulation for an erection; it doesn't cause an automatic erection. A high-fat meal can delay sildenafil absorption by about an hour. D DailyMed The sildenafil effect generally lasts for several hours. Do not take sildenafil with nitrate medicines such as nitroglycerin or isosorbide because of the risk of a dangerous blood-pressure drop. If you tell me which Cenforce D strength you have (e.g., 50/30 or 100/60), I can explain its expected timing and duration more specifically.