Malegra DXT is a combination medication used to treat erectile dysfunction (ED) and premature ***** (PE). It contains Sildenafil Citrate (the same active ingredient in Viagra) and Dapoxetine (a selective serotonin reuptake inhibitor (SSRI)), which is used to treat premature *****. The combination of these two active ingredients helps improve erectile function and delay *****. Contraindications of Malegra DXT: There are several situations in which Malegra DXT should not be used. These are considered contraindications, as they can lead to serious side effects or complications. Here's a detailed look: 1. Allergy to Active Ingredients or Excipients: Malegra DXT should not be taken if you are allergic to Sildenafil, Dapoxetine, or any of the other ingredients (excipients) in the medication. Symptoms of an allergic reaction include itching, rash, difficulty breathing, or swelling (especially of the face, tongue, or throat). 2. Nitrate Medications (e.g., Nitroglycerin): Sildenafil (one of the active ingredients in Malegra DXT) can interact with nitrates (medications used to treat chest pain, angina, or heart conditions) to cause a severe drop in blood pressure. Common nitrate medications include nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate. Combining Malegra DXT with these drugs can result in life-threatening hypotension (low blood pressure).