If Tadarise Black 80 mg contains tadalafil 80 mg, people with diabetes should use particular caution. Diabetes itself does not automatically rule out tadalafil, but diabetes can cause nerve and blood-vessel damage that contributes to erectile dysfunction. Possible benefit: Tadalafil can improve penile blood flow during ***** stimulation and may help with ED associated with diabetes. Blood pressure: Tadalafil can lower blood pressure. This matters if someone with diabetes also takes blood-pressure medicines or has cardiovascular disease. 80 mg is a concern: Standard tadalafil dosing for ED is substantially lower; tadalafil should be taken exactly as prescribed. An 80-mg product should not be used without medical evaluation and confirmation of its contents. Nitrates: Tadalafil must not be combined with nitrates such as nitroglycerin or isosorbide because of the risk of a dangerous blood-pressure drop. Diabetes control: Keeping blood glucose well controlled can also help reduce diabetes-related complications that contribute to ED.